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Beilstein J. Org. Chem. 2015, 11, 784–791, doi:10.3762/bjoc.11.88
Graphical Abstract
Scheme 1: Protein design and dual-functionalization of TTL: periodate cleavage, oxime ligation and CuAAC.
Figure 1: Dual-functionalization of TTL: A) MALDI–MS spectra (red: modified protein (as marked below); black:...
Figure 2: SPR measurements: A) set-up showing different binding events of the double-functionalized TTL to EC...
Beilstein J. Org. Chem. 2015, 11, 638–646, doi:10.3762/bjoc.11.72
Scheme 1: General approach to divalent or trivalent carbohydrate mimetics on the basis of aminopyran 1 or ser...
Scheme 2: Hydroxy group protection of aminopyran 1 to give compound 3, synthesis of amide 4 and subsequent de...
Scheme 3: Attempt to synthesize protected divalent compound 6. Conditions: a) succinic acid dichloride, Et3N,...
Scheme 4: HATU-mediated synthesis of divalent amide 25 and trivalent amides 27 and 29. Conditions: a) HATU, Et...
Scheme 5: Polysulfations of amides 5 and 13. Conditions: a) 1) SO3∙DMF, DMF-d7, 1 d, rt; 2) 1 M NaOH, 0 °C; 3...
Scheme 6: Polysulfation of divalent amides 21 and 22 leading to tetrasulfated amides 32 and 33. Conditions: a...
Scheme 7: Conversion of trivalent compound 27 into nonasulfated carbohydrate mimetic 34. Conditions: a) 1) SO3...
Figure 1: Structures of O-sulfated divalent amide 32 and trivalent amide 34 and their respective IC50 values ...